COVID-19 Evidence Updates
Produced: 23rd March 2020
Updated: 2nd June 2023
This is a summary of the latest evidence produced on Covid-19 from key websites such as NICE, WHO, educational resources or research trials.
Rapid Guidelines
Public Health England/MHRA/NPSA/UK Government
Vaccines
Resources from Royal Colleges and other professional bodies
Rapid Evidence Summaries
WHO Updates
Educational/Training resources for healthcare staff
R&D Trials
Original Articles
Rapid Guidelines
NICE
COVID-19 – Rapid guidelines and evidence reviews
New single guideline for managing COVID-19 in children and adults
NHS Specialty Guidelines
Public Health England/MHRA/NPSA/UK Government
Latest news and reports available here
Vaccines
NHS England Vaccination Programme Information
Published study results for Vaccines – PHE England
COVID-19 vaccination centres: operating framework – NHS England
Setting up and managing booking capacity of each vaccination centre – NHS England
Freeing up practices to support COVID vaccination – NHS England
Letter about movement of the Oxford AstraZeneca vaccine – NHS England
Resources from Royal Colleges and other professional bodies
List is being maintained by Health Education England nationally on a daily basis –Updated 2nd November 2021
https://healtheducationengland.sharepoint.com/:w:/s/KMTeam/EWwM4EKrAA5ErfuWdBFKk6EBzGKnumeKNLSlKMQcwezSuw?e=pdfoR0 [copy and paste in Chrome Browser]
Rapid Evidence Summaries
Rivaroxaban for Prevention of Thrombotic Events, Hospitalization, and Death in Outpatients With COVID-19: A Randomized Clinical Trial.
Accuracy of saliva for SARS-CoV-2 detection in outpatients and their household contacts during the circulation of the Omicron variant of concern.
Reparixin improves survival in critically ill and transplant patients: A meta-analysis.
Evaluation of Waning of SARS-CoV-2 Vaccine-Induced Immunity: A Systematic Review and Meta-analysis.
Efficacy and Safety of a Protein-Based SARS-CoV-2 Vaccine: A Randomized Clinical Trial.
Long-term risk of herpes zoster following COVID-19: A retrospective cohort study of 2 442 686 patients.
Risk of thromboembolism in patients with COVID-19 who are using hormonal contraception.
Nirmatrelvir-ritonavir compared with other antiviral drugs for the treatment of COVID-19 patients: A systematic review and meta-analysis.
Discontinuation of Antihypertensive Drug Use Compared to Continuation in COVID-19 Patients: A Systematic Review with Meta-analysis and Trial Sequential Analysis.
Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis.
Major Update: Masks for Prevention of SARS-CoV-2 in Health Care and Community Settings-Final Update of a Living, Rapid Review.
The clinical efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.
Cost-effectiveness of COVID-19 vaccination: A systematic review.
COVID-19 in Morocco’s region: Observational study of prevalence in symptomatic adults using the PANBIOS(R) rapid antigen test September 2021.
Long-term post-acute sequelae of COVID-19 infection: a retrospective, multi-database cohort study in Hong Kong and the UK.
Phase 2 randomised placebo-controlled trial of spironolactone and dexamethasone versus dexamethasone in COVID-19 hospitalised patients in Delhi.
Antiandrogens for the treatment of COVID-19 patients: A meta-analysis of randomized controlled trials.
Clinical efficacy and safety of interleukin-1 blockade in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials.
A Multicenter Randomized Controlled Trial To Evaluate the Efficacy and Safety of Nelfinavir in Patients with Mild COVID-19.
External validation of triage tools for adults with suspected COVID-19 in a middle-income setting: an observational cohort study.
Performance of the VitaPCR rapid molecular test for SARS-CoV-2 screening at hospital admission.
A phase 3, randomised, double-blind, placebo-controlled clinical trial evaluation of the efficacy and safety of a SARS-CoV-2 recombinant spike RBD protein vaccine in adults (ABDALA-3 study).
Effect of P2Y12 Inhibitors on Organ Support-Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial.
Rivaroxaban to prevent major clinical outcomes in non-hospitalised patients with COVID-19: the CARE – COALITION VIII randomised clinical trial.
Previous Rapid Evidence Summaries
WHO Updates
Latest WHO Situation reports are available from here
Educational/Training resources for healthcare staff
This list is being maintained by Health Education England nationally on a daily basis – Updated 18th August 2021 https://healtheducationengland.sharepoint.com/:w:/s/KMTeam/EbR7jVTQJH9Ghm7A1XJYMVcBA4ag0gS5rLKGYCg9khD8Fw?e=NReO0z [copy and paste in Chrome Browser]
COVID-19 –BMJ Best Practice Evidence Summary [Access via SWB Athens Login]
Management of coexisting conditions in the context of COVID-19 [Access via SWB Athens Login]
UpToDate topics on COVID-19
Patient Education: Understanding COVID-19 and How to Stay Safe
BMJ Talk Evidence Podcast
Elearning for Healthcare Coronavirus programme
Health and Care Video Library FREE for National Use –access a video library of over 600 health and care videos free of charge for 6 months aimed at NHS clinicians and patients
PHE-led studies on COVID-19
Patient safety during COVID-19 –Supported by Academic Health Sciences Network
Cochrane Special Collections Coronavirus (COVID-19): evidence relevant to critical care
Cochrane Special Collections Coronavirus (COVID-19): infection control and prevention measures
Cochrane Special Collections Coronavirus (COVID-19): effective options for quitting smoking during the pandemic
Cochrane Special Collections Coronavirus (COVID-19): regional anaesthesia to reduce drug use in anaesthesia and avoid aerosol generation
Cochrane Special Collection Coronavirus (COVID-19): remote care through telehealth
Cochrane Special Collection Coronavirus (COVID-19): optimizing health in the home workspace
BMJ’s Coronavirus (covid-19) Hub Free resource for all healthcare professionals
Coronavirus – COVID 19 –NICE CKS Summaries
COVID-19 (Novel Coronavirus) –DynaMed Evidence Summary
COVID-19 articles and books freely available from Wiley Publishers
COVID-19 resource centre for nurses from RCNi
Coronavirus (COVID-19): evidence relevant to critical care
Coronavirus (COVID-19): infection control and prevention measures
Elsevier COVID-19 Clinical Tool Kit
The Lancet COVID-19 archive centre for research on COVID-19
NEJM resources on COVID-19 [Ask SWB Library staff for full text if needed]
Springer Nature resources on SARS-CoV2 and COVID-19
Emerald Open Research on COVID-19
Free articles on Coronavirus available from ScienceDirect platform [requires one time registration]
Nursing articles on COVID-19 from MAG Online Library [email swbh.library@nhs.net for full text if unable to access]
R&D Trials
Studies defined as Urgent Public Health Research Studies for COVID-19 are a high priority for all organisations receiving NIHR funding. The portfolio is changing rapidly and can be found at https://www.nihr.ac.uk/covid-19/urgent-public-health-studies-covid-19.htm.
Not all of the portfolio is suitable for delivery within Sandwell & West Birmingham NHS Trust, nor are all studies open to additional centres. Where a study is to be open R&D are carrying out expedited capacity and capability assessment and study set up to ensure timely activation of studies to which we can contribute.
For more information about specific studies, please contact Gina Dutton, Head of Research and Development or the relevant Principal or Co-investigators.
SWB COVID-19 Research Trials
UK COVID Trials still recruiting patients
Published study results for Vaccines
PREPRINT: Do antibody positive healthcare workers have lower SARS-CoV-2 infection rates than antibody negative healthcare workers? Large multi-centre prospective cohort study (the SIREN study), England: June to November 2020
Original Articles
COVID-19 Study Register The aim of the register is to support rapid evidence synthesis by all systematic review producers, including Cochrane’s work on Rapid Reviews in response to COVID-19.
COVID-19 Search Bank – Literature search results conducted by healthcare librarians across England
Dimensions is a one-stop shop for all COVID-19 related information.
A living map of the evidence of studies on COVID-19 identified in MEDLINE and EMBASE that groups the evidence into broad themes.
medRxiv –Preprint repository for COVID-19 and SARS-CoV-2
Caution: Preprints are preliminary reports of work that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
If you need literature search on COVID-19 related to a condition in a specific patient population, please email your request to swbh.library@nhs.net
Produced by SWB Library and Knowledge Services
Email: swbh.library@nhs.net Tel: 0121 5073587 
@SWBHLibrary